Marissa Schuh , Integrated Pest Management Extension Educator, University of Minnesota Extension. Reviewed by Annie Klodd. Originally published April 2021, updated 2026. With their long season and spreading growth habit, pumpkins often present a weed control challenge. Here are some important factors and considerations when working to manage weeds in pumpkins and winter squash. Waterhemp in a pumpkin patch. While a few sporadic weeds may seem insignificant, one average waterhemp plant produces about 250,000 seeds. Photo: Annie Klodd, University of Minnesota Extension. First, know your weeds. This is beyond knowing you have general issues with grasses or broadleaves. Some cultural techniques and herbicide chemistries are more effective against some weeds than others. Being familiar with the specific weed issues in the fields you are planting into will help you tailor your weed control program for success. Most farms have three to four main problem weeds, so ...